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Exercise training increase antioxidant enzyme capacity and protect the shortening of telomere length
Author(s) -
Shin YunA,
Lim KangIl,
Jun TaeWon,
Song Wook
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a579
Subject(s) - telomere , oxidative stress , antioxidant , antioxidant capacity , white blood cell , medicine , biology , endocrinology , dna , biochemistry
Purpose: Telomere is essential for stabilization and protection of chromosomal ends from recombination, fusion and degradation, and for the regulation of cell replicative capacity. It has been shown that the rate of telomere shortening is dependent on the balance between oxidative stress and antioxidant defense. The purpose of this study was to investigate the effect of exercise training on telomere length in white blood cell and also whether the changes of oxidative stress and antioxidant defense relate to that of telomere length after exercise training. Methods: Sixteen sedentary healthy women were randomly divided into exercise training (Ex, n=8) and control group (Con, n=8). Ex group performed aerobic exercise (3 days/wk for 60 min at 60% VO 2 max) for 6 months. DNA was extracted from leukocytes in peripheral blood and their telomere lengths were measured by real time PCR analysis. Results: After exercise training, GPx (p<.01) and MDA (p<.05) were significantly increased and telomere length was maintained in Ex group. Even though the control group exhibited no significant change in telomere length, there was a tendency of decreased. Also, significant correlation was found between the changes of telomere length and GPx activity(r=.497, p<.05). Conclusion: These results indicate that exercise‐induced variations in antioxidant enzyme may be relevant in maintaining the telomere length.