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INFLUENCES OF A DIETARY SUPPLEMENT IN COMBINATION WITH AN EXERCISE AND DIET REGIMEN ON ADIPOCYTOKINES AND ADIPOSITY IN WOMEN WHO ARE OVERWEIGHT
Author(s) -
Fragala Maren S.,
Kraemer William J.,
Volek Jeff S.,
Spiering Barry A.,
Hatfield Disa L.,
Vingren Jakob L.,
Ho Jen Yu,
Forsythe Cassandra E.,
Puglisi Michael J.,
Anderson Jeffrey M.,
Maresh Carl M.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a578-c
Subject(s) - adiponectin , medicine , endocrinology , adipokine , overweight , leptin , placebo , obesity , insulin , regimen , weight loss , body weight , insulin resistance , alternative medicine , pathology
The influence of a soluble polysaccharide dietary supplement (Trisynex, Imagenetix, Inc., San Diego, CA) containing a blend of esterified fatty acids and hydroxypropyl‐methylcelluloses on adipocytokine and regional body composition responses to a weight loss program was examined. Twenty‐two women (Supplement group (S) (n=11): age= 36.8±7.2 y; weight=87.4 ±6.1 kg; % body fat= 43.6±7.1); Placebo group (P) (n=11): age = 38.3±6.8 y; weight = 88.3±7.2 kg; % body fat=44.2±8.2) completed an 8‐week placebo‐controlled, double‐blind study consisting of a caloric restricted diet and cardiovascular exercise. Body composition and serum insulin, leptin, and adiponectin were assessed at pre‐, mid‐, and post‐intervention. From pre‐ to post‐intervention, significant decreases (p<0.05) were observed for body weight (S: 87.4±6.1 to 78.2±3.4 kg; P: 88.3±7.2 to 82.9±4.1 kg) (p<0.05 S vs P), % body fat (S: 43.6±7.1 to 36.2±4.4; P: 44.3±8.2 to 40.9±4.3) (p<0.05 S vs P), leptin (S: 28.2±6.1 to 16.3±3.4 μg·ml −1 : P: 29.3±9.1 to 19.7±3.3 μg·ml −1 ) (p<0.05 S vs P), and insulin (S: 7.2±2.2 to 5.4±2.4 mU·L −1 ; P: 7.7±2.2 to 5.2±2.7 mU·L −1 ). Serum adiponectin increased (p<0.05) (S: 12.2±3.1 to 26.2±3.4 μg·ml −1 : 12.6±4.2 to 21.7±4.3 μg·ml −1 ) (p<0.05 for S vs P). Data indicated that Trisynex used during an 8‐week weight loss/exercise program exhibited favorable effects on adipocytokines and regional body composition. Supported in part by a grant from Imagenetix, Inc., San Diego, CA