Premium
MMP mRNA expression in the skeletal muscle following a 5 week training program
Author(s) -
Strömberg Anna,
Rullman Eric,
Rundqvist Helene,
Norrbom Jessica,
Gustafsson Thomas
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a576
Subject(s) - skeletal muscle , matrix metalloproteinase , medicine , strength training , blood flow , training effect , physical medicine and rehabilitation , training (meteorology) , endocrinology , physical therapy , cardiology , physics , meteorology
11 subjects performed one‐legged exercise program for 5 weeks. The subjects exercised one leg for 45 min with restricted blood flow, followed by exercise with the other leg at the same absolute workload with unrestricted blood flow. Gene expression of MMP‐2, ‐9, ‐14 and TIMP‐1 were measured in m vastus lateralis before and after the training period, as well as 2 h after the first and last exercise bouts. MMP‐14 and MMP‐2 both increased robustly with training regardless of training condition, but with no increase after a single exercise bout. MMP‐9 increased transiently after a single bout of exercise in the restricted leg, but no increase was evident with training. TIMP‐1 had a tendency to increase after a single bout of exercise in the restricted leg and increased with training in both conditions, however more in the restricted leg. This support the importance of MMP for the adaptation and remodelling of the skeletal muscle with exercise training. The difference in expression of MMP‐9 and TIMP‐1 between the exercise conditions supports a role of oxygen delivery in their expression. The uniform behaviour of MMP‐2 and MMP‐14 regardless of exercise condition imply other mechanisms behind their expression.