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Maximal exercise recovery as a potential means for assessing sympathetic overactivity related to insulin resistance
Author(s) -
Yeckel Catherine Weikart,
Gulanski Barbara,
Lopes Melinda,
Dziura James,
Parish Rebecca,
Sherwin Robert
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a575
Subject(s) - insulin resistance , medicine , heart rate , endocrinology , insulin , balance (ability) , sympathetic nervous system , insulin sensitivity , cardiology , heart rate variability , blood pressure , physical therapy
Autonomic nervous system balance likely influences the link between health risk and cardiovascular disease. Early exercise heart rate recovery is tied to risk associated with parasympathetic dysfunction. The initial recovery plateau region represents sympathetic withdrawal —to regain sympathovagal balance. We investigated whether the initial plateau region in exercise recovery heart rate (HR) normalized for oxygen consumption (VO 2 ) could provide a novel index for apparent sympathetic overactivity associated with insulin resistance. Methods: A healthy young cohort (n=20), body fat 9–50% was studied using a maximal fitness test (cycle). Heart rate and VO 2 measurements were continued for 3 minutes into recovery. Fasting and stimulated insulin sensitivity (OGTT‐derived) measurements were also determined. Results: Parasympathetic function was normal, and unrelated to insulin resistance. The proposed index for sympathetic overactivity, HR 2‐3min /VO 2(2‐3min) , ranged from 9 to 34 bpm/(ml/kg·min). We found this index was related to both OGTT‐derived whole body insulin sensitivity index r= −0.73, p<0.001 and fasting insulin resistance (HOMA‐IR) r=0.74, p<0.001. The primary determinant of this relationship was insulin level (r=0.69, p<0.001), not glucose. Conclusion: Recovery from maximal exercise may provide a simple means to evaluate sympathetic overactivity associated with insulin resistance.