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Statin treatment does not affect exercise induced cardiac hypertrophy (EICH)
Author(s) -
Nelson Matthew Jay,
Can Megan,
Starnes Joseph W.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a571-d
Subject(s) - medicine , muscle hypertrophy , cardiology , cardiac function curve , heart rate , treadmill , cardiac hypertrophy , analysis of variance , blood pressure , heart failure
Statins attenuate pathological cardiac hypertrophy, but how they affect EICH is unknown. To address this female S‐D rats were divided into four groups: sedentary (S), Simvastatin (ST) (10mg/kg/day orally), exercised on a treadmill for 5 days/wk up a 6° incline for 5 weeks (E) or E+ST. Animals were trained progressively, in an 8° C room, during the last week they were running 1 hr at 30 m/min. Hearts were weighed and function was evaluated under low and high afterloads using an isolated perfused working heart preparation. Performance variables included: peak systolic pressure (SP), cardiac output (CO), coronary flow, external work (COxSP), oxygen consumption, and efficiency of work (EFF). A 2×2 ANOVA was performed and the αset at 0.05 to determine significance. Main effects for exercise were found for skeletal muscle cytochrome oxidase as well as the heart weight and heart weight/body weight (P<0.05). At the high workload a main effect for exercise occurred for all performance variables (P<0.05). When normalized for heart weight, increases in COxSP, VO2 and EFF were still present (P<0.05). No main effects for statins or interactions were found for any variable under high or low workloads. In conclusion statin therapy does not affect EICH. Not only did the exercised hearts hypertrophy but when expressed per gram they were functionally better. Supported by AHA Texas Affiliate