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Interaction of Magnolol and exercise training on blood oxidative stress and aortic adhesion molecules in hyperlipidemic rabbits
Author(s) -
Chang WengCheng,
Tsai JongChang,
Chen YuWei,
Yu YaMei
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a570-a
Subject(s) - magnolol , malondialdehyde , medicine , oxidative stress , blood lipids , hyperlipidemia , pharmacology , cholesterol , endocrinology , diabetes mellitus
This study was aimed to investigate the interaction of Magnolia officinalis and exercise training on attenuating the process of atherosclerosis of the cholesterol‐fed rabbits. The results showed an addictive effect of Magnolol supplement and exercise training on preventing the aortas of the hyperlipidemic rabbits from atherosclerotic lesion. On the biochemical level, serum low‐density lipoprotein (LDL) and total cholesterol (TC), blood malondialdehyde (MDA) levels, and P‐selectin levels of the aortic arches were synergistically reduced in the hyperlipidemic rabbits by combination of exercise training and Magnolol supplement. Nonetheless, blood free radical counts, aortic SOD‐1 and VCAM‐1 levels were not addictively reduced in the hyperlipidemic rabbits co‐treated with exercise training and Magnolol supplement. On morphological study, lipid lesions of the aorta resulted from high‐fat diet were fully prevented in the combined treatment of exercise training and Magnolia extract. This study indicates that co‐treatment of exercise training and Magnolol supplement exert synergistically and could be a promising alternative therapy for atherosclerosis.