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CARDIOVASCULAR AND PULMONARY EFFECTS OF NOS INHIBITION IN ENDOTOXEMIC CONSCIOUS RATS SUBMITTED TO SWIMMING TRAINING
Author(s) -
Mehanna Aida,
Blanco Eleonora Abra,
PingeFilho Phileno,
MartinsPinge Marli Cardoso
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a570
Subject(s) - medicine , sepsis , femoral artery , blood pressure , nitric oxide , mean arterial pressure , perfusion , anesthesia , edema , pulmonary artery , heart rate , cardiology , pharmacology
Sepsis is characterized by systemic hypotension, hyporeactiveness to vasoconstrictors, impaired tissue perfusion, and multiple organ failure. During exercise training (ET) dynamic cardiovascular adjustments take place to maintain proper blood pressure and adjust blood supply to different vascular beds. The objective was verify if ET has preventive effect to the cardiovascular abnormalities induced by LPS, a model of experimental endotoxemia, and evaluate the role of nitric oxide (NO) in pulmonary edema index (PEI). Wistar rats were submitted to swimming training (1 hour; 5 days/week, 4 weeks). After ET the rats were submitted to catheterization of femoral artery and vein. LPS (5 mg/kg/ml, iv) administration in control (C) and trained animals (ET) showed 3 distinct phases in mean arterial pressure (MAP) and heart rate (HR). After ET the alterations in MAP and HR were attenuated. The ET animals showed a lower PEI (C=0,65±0, 01; ET=0,60±0,02), which was attenuated after treatment with aminoguanidine for both groups (C=0,53±0,02; ET=0,53±0,02). After L‐NAME, PEI enhanced in the C group but it was higher in the ET rats (C=0,73±0,05; ET=1,30±0,3). The cardiovascular adaptations promoted by ET seem to be beneficial to counteract the cardiovascular abnormalities seen in septicemia induced by LPS, and constitutive NO seems to participate in this process.