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Modeling Mechanical Determinants of Skeletal Muscle Perfusion
Author(s) -
Shoemaker J. Kevin,
Zamir Mair
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a563-a
Subject(s) - vasomotor , viscoelasticity , perfusion , compliance (psychology) , anatomy , mechanics , cuff , brachial artery , flow (mathematics) , biomedical engineering , cardiology , physics , medicine , blood pressure , surgery , thermodynamics , psychology , social psychology
Current understanding of vasomotor regulation in skeletal muscle is based largely on changes in vascular resistance (R) that, in turn, reflects changes in vessel caliber. While this deals adequately with the steady component of flow, it neglects vessel compliance (C) which is a major determinant of the oscillatory component of flow. In this study we consider a modified Windkessel model (RCKL) in which the effects of R and C are examined along with those of fluid inertia (L) and viscoelasticity (K) of the vessel wall. The model is used to calculate a flow wave that results from a measured pressure wave; the computed wave is verified by comparison with one measured concurrently with the pressure wave. Values of R,C,K,L, required to produce agreement between the two waveforms are then recorded. The model was tested using brachial artery pressure (Millar) and flow (Doppler ultrasound) waveforms that were measured concurrently in a single individual during before and after altering R using wrist occlusion, and with the arm positioned level with, and above, heart level to change C independently of R. In (1) R increased 4‐fold with minimal change in C, while in (2) C increased 2‐fold with no change in R. Thus, the model offers an extended probe to study vasomotor regulation. Supported by the NSERC‐CIHR Collaborative Health Research Program