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Pontomedullary transection alters the intrinsic interactions of fast oscillatory rhythms in inspiratory motor discharges in arterially‐perfused adult rat
Author(s) -
Chen Xinnian,
Chon Ki H,
Solomon Irene C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a561-c
Subject(s) - brainstem , neuroscience , rhythm , bursting , basal (medicine) , central pattern generator , physics , biology , medicine , insulin
Recent work from our laboratory in the arterially‐perfused adult rat preparation has demonstrated that transection of the brainstem at the pontomedullary (PM) border elicits multiple patterns of inspiratory motor output. These modified inspiratory bursts exhibit alterations in spectral dynamics albeit, the changes are not identical for all of the burst patterns observed, suggesting that the intrinsic interactions amongst network components may be differentially expressed. To evaluate this possibility, we implemented bispectrum analysis to examine nonlinear interactions in phrenic bursts before and following PM transection. For these analyses, we examined PM transection‐induced fractionated, square wave, bell‐shaped, augmenting, and decrementing phrenic burst patterns. Under baseline conditions, interactions were seen predominantly within the HFO range. Following PM transection, the incidence of interactions in the HFO range was reduced for all, but the fractionated, modified bursts (P<0.01), and MFO self‐coupling occurred in many of the modified bursts (P<0.02). Interactions between the HFO and higher frequencies were also reduced (P<0.02) in the modified bursts. These results demonstrate that nonlinear interactions exists in the fast oscillatory rhythms underlying basal phrenic bursts, and that following PM transection, the modified bursts are associated with an alteration in the intrinsic interactions between self and different subunits of the central inspiratory network. Supported by NS045321 and NS049310