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Tempol prevents vascular remodeling in stroke prone spontaneously hypertensive rats (SHRSP).
Author(s) -
Dorrance Anne M,
Deutsch Christian
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a525-a
Subject(s) - lumen (anatomy) , medicine , pathogenesis , stroke (engine) , reactive oxygen species , middle cerebral artery , superoxide dismutase , endocrinology , cardiology , oxidative stress , ischemia , chemistry , biochemistry , mechanical engineering , engineering
Increased reactive oxygen species (ROS) production is involved in the pathogenesis of hypertension and stroke. The effects of ROS on cerebral blood vessels from hypertensive rats has not been studied, we hypothesized the tempol the super oxide dismutase mimetic would prevent remodeling of the middle cerebral artery (MCA) in SHSRP. Six week old male SHRSP were treated with Tempol (1mmol/L) for six weeks. At twelve weeks of age the MCA was removed and mounted in a small vessel arteriograph to study passive vessel structure under zero flow and calcium free conditions. Tempol caused a dramatic increase in the MCA lumen diameter (245.5 ± 5.3 vs 195.2 ± 12.0μm tempol vs control) and a reduction in vessel wall thickness (35.1 ± 1.4 vs 38.0 ±4.1μm tempol vs control). This change was reflected in a reduction in the wall/lumen ratio (0.14 ± 0.01 vs 0.21± 0.04 tempol vs control) and an increase in the lumen area (47536 ± 2846 vs 30457 ± 3277 μm 2 tempol vs control). These studies suggest that ROS production is involved in cerebral vessel remodeling in SHRSP in a manner that would promote stroke and that tempol prevents this process.