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Electrical stimulation of the dorsal spinal column at T12‐T13 increases renal sodium excretion but not renal blood flow
Author(s) -
Stearns Angela Lea,
Knoblich Penny R
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a508-c
Subject(s) - renal blood flow , medicine , stimulation , renal artery , urology , anesthesia , kidney , chemistry
Prior studies in this laboratory found an ipsilateral increase in renal sodium excretion in the spontaneously hypertensive rat (SHR) following dorsal spinal column stimulation (DSCS) in the area associated with the left renal sensory nerves (T12‐T13). The current study examined the effect of DSCS on renal blood flow (RBF), mean arterial pressure (MAP), and heart rate (HR). Methods: Male SHR underwent a sham surgery, or received left DSCS at T12‐T13 during the second of six 15‐minute collection periods. The carotid artery, jugular vein, and bladder were cannulated, and stimulation was performed with a ball electrode at 66% of the motor threshold (0.2 msec duration and 50 Hz). RBF was measured with a Transonic flow probe, and MAP and HR were recorded continually. Urine was collected and analyzed using flame photometry. Results: Renal sodium excretion increased over baseline values in collection periods 3 and 4 in the DSCS group, but did not significantly increase in the sham group until period 6. RBF did not differ significantly when compared to baseline values, between groups, or between the ipsilateral and contralateral kidneys. MAP and HR were unchanged in the DSCS group when compared to baseline values, or to the sham group. Conclusion: DSCS increases renal sodium excretion independent of alterations in renal blood flow or sympathetic tone. (Funded by Biological Sciences, Minnesota State University.)