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Water and salt intake in rats with hepatic cirrhosis
Author(s) -
Matthews Kristen,
Ji Lisa L.,
Lumia A. R.,
Cunningham J. Thomas
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a507-b
Subject(s) - medicine , endocrinology , appetite , vasopressin , cirrhosis , sodium , plasma osmolality , chemistry , organic chemistry
The bile duct ligated (BDL) rat is an animal model of hepatic cirrhosis that is associated with changes in body fluid balance. The present study examines changes in drinking behavior and sodium appetite in BDL rats. Rats received either BDL (n= 12) or sham ligation (n=9) 3–4 weeks prior to the experiments. BDL produced significant increases in plasma vasopressin (Sham 6.5 ± 2, BDL 37 ± 10 pg/ml; P < 0.01) and plasma renin activity (Sham 6.3 ± 4, BDL 15.8 ± 4 ng/ml/min; P <0.01). BDL rats were also significantly hypervolemic with decreased plasma osmolality. Liver weight to body weight ratios were significantly increased in BDL rats. Water intake produced by isoproterenol (30 ug/kg sc) or 6% NaCl (1 ml/100g bw, sc) was not significantly effected by BDL (isoproterenol: Sham 6.5 ± 1.1; BDL 7.1 ± 2.0 ml; 6% NaCl: Sham 8.6 ± .8; BDL 10.4 ± 2.6 ml; both P > 0.05). However, BDL rats drank significantly more water than sham rats following injection of 0.9% NaCl (Sham 1.86 ± .5; BDL 4.8 ± .6 ml; P < 0.05). A separate group of Sham and BDL rats were examined for sodium appetite following 24 hour fluid deprivation. Prior to the test, the daily average 1.5% NaCl intake was significantly increased in BDL rats (Sham 15.1 ± 3, BDL 38.3 ± 8 ml; P <0.05) as was total fluid intake (Sham 47.7 ± 5; BDL 67.2 ± 5; P < 0.05). After 24 h fluid deprivation, water intake was not different between the groups (Sham 14.0 ± 4, BDL 11.3 ± 4, P > 0.05) and there was a trend for increased 1.5% NaCl intake in BDL rats (Sham 14.25 ± 2, BDL 21.3 ± 3, P > 0.05). The results indicate that BDL alters daily sodium intake without affecting daily water intake. ( HL062579 , DK57822)