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Orthostatic stress increases thirst in congestive heart failure rats
Author(s) -
Zheng Can,
Li Meihua,
Kawada Toru,
Sugimachi Masaru
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a507-a
Subject(s) - thirst , heart failure , medicine , ingestion , endocrinology , orthostatic vital signs , cardiology , blood pressure
Background: Thirst is a common and troublesome symptom for patients with congestive heart failure (CHF). The determinants of thirst have important implications for guiding clinical management. Orthostatic stress (OS) is unavoidable for CHF patients. We hypothesized that OS may be one of the crucial factors to cause thirst in CHF. This study investigated thirst responses to OS in sham and CHF rats. Methods: Coronary artery occlusion in 8 weeks old rats were raised for 12 weeks to cause CHF. Ether sham or CHF rats were moved from standard cage to a high roof cage (H=33cm) where rats had to stand up to get food or water (defined as OS). A real‐time monitoring system was used to record water consumption (implied as thirst) of individual animals. Results: In the standard cage, there was no significant difference of daily water consumption between sham and CHF rats (73±12 vs.66±5.9 g/Kg/day, p>0.05). But CHF rats prolonged drinking interval (1.0±0.21 vs. 1.5 ±0.22 hr, p<0.05). Response to OS, sham rats decreased daily water intake by 17.5% (p<0.01); CHF rats significantly increased by 13.3% (p<0.05). Conclusion: The results suggested that response to osmotic changes in CHF rats were attenuated. In response to OS, sham rats may decrease the water excretion by nurohumoral mechanisms to compensate circulatory volume; however, CHF rats increase water ingestion due to great thirst.