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Differences in nephron to nephron interactions between Sprague‐Dawley (SDR) and spontaneously hypertensive rats (SHR)
Author(s) -
Siu Kin Lung,
Yip KayPong,
Chon Ki H.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a500-b
Subject(s) - bispectrum , nephron , tubuloglomerular feedback , medicine , endocrinology , coupling (piping) , chemistry , kidney , neuroscience , biology , mathematics , mechanical engineering , statistics , spectral density , engineering
Our previous work using the auto‐bispectrum revealed nonlinear interactions between the myogenic and TGF mechanisms in both the whole kidney and single nephron measurements from SDR and SHR. Our aim in this study was to investigate if nephrons located on the same radial artery also show such nonlinear interactions. To this end, stop flow pressure (SFP) from two nephrons were simultaneously measured from both SDR (n=12) and SHR (n=18). Vascular connections between nephrons were confirmed with vascular cast. Cross‐bispectrum between the two SFP measurements was calculated to detect coupling. The statistical significance of the presence of nonlinear interactions found via cross‐bispectrum was tested against surrogate data realizations. Results show that most of the nephron pairs have significant coupling between the tubuloglomerular (TGF) and myogenic (MYO) mechanisms (10 out of 12 and 13 out of 18 SFP records for SDR and SHR, respectively), while only a few have MYO to MYO coupling (2/12 and 2/18) for both stains of rats. TGF to TGF coupling was more prevalent in SHR (10/18) than SDR (4/12). This enhanced TGF to TGF coupling between nephrons in SHR may be an indication of enhanced autoregulatory function associated with SHR.