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The direction of vasodilatory conducted responses is dependent on the vascular site in which they are initiated
Author(s) -
Junuzovic Jasna,
Murrant Coral L.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a486-d
Subject(s) - vasodilation , cremaster muscle , stimulation , arteriole , anatomy , pinacidil , hamster , chemistry , biophysics , medicine , biology , endocrinology , microcirculation , glibenclamide , diabetes mellitus
In skeletal muscle tissue, blood flow matches metabolism such that increases in blood flow are directed to active skeletal muscle fibers via coordinated vasodilations to upstream vessels. To study the spread of vasodilation, we examined hamster cremaster arteriolar dilations in situ to micropipette application of 10 −5 M pinacidil (PIN, a K ATP channel opener) for 2 minutes onto either a TA, a BA or the CAPS and observed conducted responses at upstream and downstream sites including MIs (figure 1). Stimulation of the TA induced dilations that conducted to both upstream and downstream sites along the TA (3.8+/−1.3, 4.2+/−0.9um) and to BAs and MIs both upstream (3.4+/−1.1, 1.1+/−0.2um) and downstream (2.1+/−0.3, 0.8+/−0.3um) from the site of application. Stimulating the BA induced conducted dilations to the TA and the BA but upstream only (4.2+/−1.6, 0.9+/−0.3um). Similarly, stimulating the CAPS induced dilations of the MI, BA and TA upstream to and directly supplying the stimulated CAPS (2.1+/−0.4, 1.4+/−0.5, 1.6+/−0.5um), but not other MIs associated with the same BA. Therefore, BA and CAPS stimulation induced directional upstream conduction of vasodilation to vessels which directly supply the site of stimulation, while TA stimulation did not produce similar directional dilations. This demonstrates that the direction of the conducted responses appears to be dependent on the site of stimulation. NSERC and PREA. 1Schematic of hamster cremaster vasculature