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Theoretical investigation of temperature elevation in rat limb during magnetic particle hyperthermia
Author(s) -
Salloum Maher,
Ma Ronghui,
Zhu Liang
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a478-b
Subject(s) - ferrofluid , materials science , hyperthermia , magnetic nanoparticles , magnetic field , particle size , particle (ecology) , nanoparticle , elevation (ballistics) , thermal , nuclear magnetic resonance , heat generation , magnetic hyperthermia , mechanics , composite material , thermodynamics , chemistry , nanotechnology , physics , meteorology , geology , oceanography , quantum mechanics , astronomy
Magnetic ferrofluid hyperthermia has been proposed for inducing irreversible thermal damage to deep seated tumors. Ferrofluid usually consists of nanoparticles and physiological solution. Previous studies have shown that magnetic nanoparticles delivered to tissue can induce localized heating when it is exposed to alternating magnetic field. In this study, we first simulate the electromagnetic field to quatify heat generation distribution induced by the ferrofluid. The Pennes bioheat equation is then used to evaluate temperature elevation in a rat limb when nanoparticles are injected to the center of the limb. Temperature elevation at the center of particle delivery can be as high as 18°C induced by nanoparticles of 13 nm dia. when exposed to 250 kHz alternating electromagnetic field. The heat generation by the particles and temperature elevation become smaller as the frequency decreases. At each frequency, an optimal particle size is identified to achieve a maximum temperature elevation. At 250 kHz, the ideal particle size is around 13 nm in diameter. This optimal particle size tends to become bigger when the frequency is smaller. Our simulation results have suggested that ferrofluid is capable of generating substantial temperature elevation in tissue when exposed to a relatively small magnetic field. It helps understand thermal transport in tissue and optimize heat generation and temperature elevation in future studies.