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Central neuropeptide S decreases feed intake and locomotor activity while increasing plasma corticosterone in chicks.
Author(s) -
Godlove David Christian,
Cline Mark Andrew
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a461-b
Subject(s) - corticosterone , endocrinology , medicine , water intake , neuropeptide y receptor , anxiolytic , neuropeptide , chemistry , zoology , food intake , biology , hormone , receptor
Neuropeptide S (NPS), recently isolated in the mammalian brain, causes satiety and increases locomotion while producing anxiolytic‐like effects in rodents. Effects of NPS in avian species are unreported. Thus, 3 experiments were conducted to determine the effects of intracerebroventricular (ICV) injection of rattus NPS on 4 day post hatch 500‐Cobb chicks. In Exp. 1 chicks (n = 40) were randomly assigned to received ICV injections of 0, 1.25, 0.625, or 0.313 μg NPS. Feed and water intake were recorded at 30 min intervals cumulatively for 180 minutes post injection. NPS‐treated chicks responded with a concentration dependent, quadratic reduction in feed intake ( p < .05). Water intake was not affected. In Exp. 2, chick (n = 27) behavior was monitored automatically for 30 min. after receiving ICV injections of 0 or 0.625 μg NPS. NPS treated chicks had fewer feeding pecks, fewer drinks, spent less time moving, and traveled less distance ( p < .05). Blood samples were collected from chicks and plasma corticosterone concentrations were determined. NPS‐treated chicks had increased corticosterone concentrations ( p < .05). These results demonstrate that NPS is an anorexigenic signal with no effect on water intake and reduces locomotion while increasing anxiety in chicks. Since chick and rodent responses to central NPS differ, evolutionary divergence may exist in the NPS cascade.