Premium
Re‐feeding after long‐term caloric restriction rapidly restores heart rate and metabolic rate but slowly restores body weight and incompletely restores serum leptin
Author(s) -
Seth Rohit,
Knight W David,
Overton J Michael
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a457-a
Subject(s) - caloric theory , leptin , endocrinology , medicine , body weight , heart rate , intermittent fasting , term (time) , metabolic rate , biology , obesity , blood pressure , physics , quantum mechanics
Weight regain after short‐term caloric restriction (CR) is due to both hyperphagia and suppression of metabolism. The purpose of this study was to determine the responses to re‐feeding after long‐term CR in rats housed at 23°C. Male FBNF1 rats were studied at 12 months of age from CR or control (CON) colonies maintained by the NIA. CR rats had decreased body weight (BW; CON :408±4 CR :296±3 g), oxygen consumption (VO 2 ; CON :13.1±.2 CR :11.9±.1 ml/min/kg .075 ), and heart rate (HR; CON :305±3 CR :281±3 bpm). Re‐feeding (RF) induced hyperphagia ( CON :63±1 CR :40±0 RF‐1day :84±2 kcals) and rapidly restored VO 2 ( CON : 13.1±.2 CR :11.9±.1 RF‐1day :13.5±.2 ml/min/kg .075 ) and HR ( CON :305±3 CR :281±3 RF‐1day :302±4 bpm). Re‐fed rats regained weight at a slow rate for 2 months ( CON :408±4 CR :296±3 RF‐1wk :333±5 RF‐2mo :391±12 g). Interestingly, 2 months of re‐feeding resulted in similar visceral adipose mass as controls ( CON :12.4±.9 CR :6.4±4 RF‐1wk :9.9±.9 RF‐2mo :13.8±.8 g) but lower serum leptin values ( CON :15.5±1.0 CR :3.6±0.7 RF‐1wk :5.3±1 RF‐2mo :10.3±2.9 ng/mL). These data indicate that the physiological responses to re‐feeding are dependent upon duration of caloric restriction. Supported by NIH AG23837.