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Lipid abnormalities in young patients with attention‐deficit/hyperactivity disorder
Author(s) -
Spahis Schohraya,
Vanasse Michel,
Delvin Edgard,
Montoudis Alain,
Grenier Emilie,
Ghadirian Parviz,
Levy Emile
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a455
Subject(s) - polyunsaturated fatty acid , cholesterol , medicine , palmitic acid , fatty acid , endocrinology , oleic acid , attention deficit hyperactivity disorder , chemistry , biochemistry , psychiatry
Abnormal levels of long‐chain polyunsaturated fatty acids (PUFA), particularly omega‐3 fatty acid (FA), have been associated with a variety of behavioural deviations, including attention‐deficit/hyperactivity disorder (ADHD). The aims of our study were to define the lipid status and fatty acid composition in 37 young French‐Canadian patients with ADHD (6–12 years) matched by sex and age with 35 healthy controls. Consistent differences were noted in plasma lipids (triglycerides, total cholesterol, and phospholipids), lipoproteins (LDL‐cholesterol, HDL‐cholesterol) and apolipoproteins (Apo A‐I, Apo B‐100) of the subjects with ADHD. Furthermore, the proportion of omega‐3 FA was significantly altered as well illustrated by the decrease in alpha‐linolenic acid (ALA, p≤0.004) and the increase in EPA and DHA (p≤0.04). On the other hand, a raise of palmitic acid (p≤0.03) and a decline in oleic acid (p≤0.0001) were detected. These changes led to abnormally low ratios of PUFA/Saturates (p≤0.02), ALA/EPA (p≤0.002) and ALA/LA (p≤0.01), concomitant with a high ratio of DHA/AA (p≤0.04). Overall, this clinical survey was able to provide us with an insight into the association of ADHD with especially abnormal FA composition. Studies are underway to delineate the mechanisms.