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Control Of Translation From The mRNA 3′ End
Author(s) -
Sonenberg Nahum
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a45-c
Subject(s) - eif4g , poly(a) binding protein , eif4e , eif4a , messenger rna , microbiology and biotechnology , eukaryotic translation , translation (biology) , biology , chemistry , biochemistry , gene
The eukaryotic mRNA 3′ polyA tail acts synergistically with the 5' cap structure to enhance translation. This mechanism is effected by a bridging complex, composed of the poly (A) binding protein (PABP), eIF4G, and the cap‐binding protein, eIF4E, which brings about mRNA circularization. The bridging between the mRNA 5' and 3' ends is regulated by several different mechanisms. We have discovered proteins that bind to PABP, termed Paips ( PA BP‐ i nteracting p roteins), which control translation initiation. Paip1 stimulates translation through its simultaneous interactions with PABP, eIF4A and eIF3, while Paip2 inhibits translation by dislodging PABP from the polyA tail and by competing with eIF4G for binding to PABP. The structural basis for the function of the Paips will be discussed.