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Antibacterial Activity of some New 4‐Triazolylamino‐ and 4‐Benzothiazolylamino‐3‐Nitro‐2H‐[1]‐Benzopyran‐2‐ones
Author(s) -
Vehapi Idriz M,
Plakolli Mujë,
Kurteshi Kemajl,
Hoti Ramiz
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a441-b
Subject(s) - benzopyran , nitro , chemistry , antibacterial activity , hydrolysis , medicinal chemistry , organic chemistry , bacteria , biology , alkyl , genetics
4‐(5‐Mercapto‐1,2,4‐triazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 3a , 4‐(5‐Methylmercapto‐1,2,4‐triazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 3b , 4‐(2‐Benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 3c and 4‐(4‐Methyl‐2‐benzothiazolylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐ones 3d are synthetized by condensation of corresponding heterocyclic amines 2(a–d) and 4‐Chlor‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 1 . under the reflux reaction conditions. Alkali hydrolysis of 3(a–d) afforded the 2‐hydroxy‐ω‐nitroacetophenone 4 . Antibacterial activity of products 3(a–d) are investigated and results are submitted for their antibacterial activities against Escherichia coli Staphylococcus aureus and, Clebsiella .

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