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Synthesis of some New 4‐Pyridinylylamino‐ and 4‐Pyrimidinylamino‐3‐Nitro‐2H‐[1]‐Benzopyran‐2‐ones and their Antibacterial Activity
Author(s) -
Hoti Ramiz Sh,
Bicaj Muhamet L,
Kalaj Vuksan L,
Vehapi Idriz M,
Nura Aferdita,
Vataj Ramë
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a441-a
Subject(s) - benzopyran , nitro , chemistry , antibacterial activity , hydrolysis , medicinal chemistry , alkaline hydrolysis , organic chemistry , bacteria , biology , alkyl , genetics
4‐(3‐Hydroxy‐2‐pyridinylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4a , 4‐(3,5‐Dichlor‐2‐pyridinylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4b , 4‐(4‐Methyl‐2‐pyrimidinylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 4c and 4‐(4‐Hydroxy‐6‐methyl‐2‐pyrimidinylamino)‐3‐nitro‐2H‐[1]‐benzopyran‐2‐ones 4d are synthetized by condensation of 4‐Chlor‐3‐nitro‐2H‐[1]‐benzopyran‐2‐one 2 and corresponding heteroarylamines 3(a–d) under the reflux reaction conditions. Alkali hydrolysis of 4(a–d) afforded the 2‐hydroxy‐?‐nitroacetophenone 5 . Antibacterial activity of products 4(a–d) are investigated and results are submitted for their activities against Staphylococcus aureus, Clebsiella and Escherichia coli.