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Influence of the Angiotensin Converting Enzyme (ACE) gene Insertion/Deletion polymorphism on blood pressure and renal allograft function in children following renal transplantation
Author(s) -
Büscher Rainer,
Nagel Dominik,
Hoyer Peter F.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a438-b
Subject(s) - renal function , blood pressure , medicine , renin–angiotensin system , endocrinology , transplantation , genotype , allele , angiotensin ii , biology , gene , genetics
Preservation of a stable allograft function in children following renal transplantation (RTx) depends on various factors including blood pressure and genetic variability. Due to their impact on blood pressure regulation we have studied polymorphisms of the renin‐angiotensin‐aldosterone system and TGFβ1 in 91 children following RTx and associated genotypes with loss of glomerular filtration rate (GFR, ml/min/1.73m 2 ) and blood pressure (mean observation time 5.4 years). We studied the Renin G1883A, ACE I/D, Angiotensinogen ( AGT ) Met235Thr and Angiotensin II receptor type‐1 ( AT1R ) A1166C polymorphism as well as TGFβ1 ( TGFB1 ) C509T and Leu10Pro. Allelic frequencies were not significantly different from healthy controls. Genotypes of Renin, AGT , AT1R and TGFB1 showed no significant association with the slope of GFR but ACE DD‐carriers had a significantly steeper decline of GFR and a higher systolic and diastolic blood pressure before RTx when compared to ACE II‐carriers (slope DD‐4.289±0.832 vs. II‐1.333±1.107, p=0.035). We conclude that the ACE DD‐genotype may contribute to a faster, non immunological renal allograft failure.