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Association of NAT2 Polymorphism and Helicobacter Pylori Infection with Gastric Cancer Risk Predisposition in Omani Arab Patients
Author(s) -
Tanira Musbah O,
AlMoundhri Mansour S,
AlKindy Mohamed,
AlBahrani Bassim,
AlNabhani Maryam,
Burney Ikram A,
AlMadhani Ali,
Ganguly Shyam S
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a415-c
Subject(s) - genotype , genotyping , helicobacter pylori , medicine , cancer , gastroenterology , stomach cancer , etiology , biology , genetics , gene
The N‐acetyltransferases (NATs) are important enzymes in the activation and inactivation of various carcinogens. Epidemiological studies suggest that NAT2 acetylation polymorphisms modify the risk of developing several cancers, but the association with gastric cancer remains unclear. This study was conducted to examine whether N‐acetyltransferase 2 ( NAT2 ) genotype is a risk factor for gastric cancer in Omani patients and to study the prognostic significance of NAT2 . Genomic DNA was extracted from peripheral blood of 100 gastric cancer patients and 100 control subjects. NAT2 genotyping was performed using DNA sequencing. The prognostic significance of NAT2 and other clinicopathological features was assessed by univariate and multivariate analyses. We observed no significant association of NAT2 genotypes and phenotypes with gastric cancer risk. However a significant association was observed between gastric cancer and the slow acetylator NAT2 genotype accompanied by H. pylori infection (OR = 2.8, 95% CI: 1.3–6.0, p = 0.007) when compared with slow acetylators uninfected by H. pylori . There was no significant association between NAT2 and clinicopathological features, and NAT2 had no independent prognostic significance. The NAT2 slow acetylator genotype with concomitant H. pylori infection has an increased risk for developing gastric cancer. The etiological link is unclear, but provides the impetus for further research.