Premium
Role of vanilloid receptors in recurrent airway obstruction (RAO) in horses
Author(s) -
Venugopal Changaram,
Beadle Ralph E.,
Holmes Earnestine P.,
Moore Rustin M.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a407-a
Subject(s) - airway obstruction , medicine , airway , receptor , anesthesia
Vanilloid receptors are located in the area of the body exposed to the environment such as skin, lungs and gastrointestinal tract. These receptors are sensors in the airways that signal the events occurring in the environment to the central nervous system, and are believed to be responsible for the initiation of airway hyperreactivity. Stimulation of vanilloid receptors leads to the release of neuropeptides which induces neurogenic inflammation and bronchoconstriction. The objective of this study was to determine the pathophysiological role of vanilloid receptors in equine airway hyperractivity. This was performed in bronchial rings collected from two groups of horses, clinically healthy and RAO‐affected horses. Bronchial rings (4mm wide) were collected from the 4 th – 7 th generation branches of airways from both groups. We evaluated the response of the vanilloid receptors on the bronchial rings by stimulating them with capsaicin in an in‐vitro organ bath study. Responses were monitored for a total of 30 minutes after capsaicin was added. Results of the study showed that capsaicin induces a contractile response. A comparison of response between clinically healthy and RAO showed that capsaicin caused a greater contraction in the RAO horses. Funded by Equine Health Studies Program, LSU‐SVM