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Claudin‐1 versus EMA Staining in Low and High Grade Meningiomas
Author(s) -
Rivera Andreana Laura,
Takei Hidehiro,
Bhattacharjee Meena B,
Adesina Adekunle,
Goodman J. Clay,
Powell Suzanne Z
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a389
Subject(s) - staining , grading (engineering) , stain , pathology , claudin , meningioma , significant difference , medicine , biology , tight junction , ecology , microbiology and biotechnology
Background: Claudin‐1 has recently gained interest as a potential immunomarker for the differentiation of meningiomas from other spindle cell lesions. Our interest was to look into the staining patterns of Claudin‐1 and epithelial membrane antigen (EMA) in Grade I, II, and III (GI‐III) meningiomas to determine if there is a difference in staining based on tumor grade. To our knowledge, no previous studies have specifically compared Claudin‐1 and EMA staining in low and high grade meningiomas. Design: 72 meningiomas were selected and WHO 2000 grading criteria was applied to all cases. Final grading of the 72 cases revealed 20 GI, 45 GII, and 7 GIII meningiomas. The cases were divided into low grade (GI) and high grade (GII‐III) groups. All cases were stained with Claudin‐1 and EMA. Results: Claudin‐1 positivity was seen in 85% low grade (LG) and 60% high grade (HG) meningiomas. EMA was positive in all meningiomas. In the LG cases Claudin‐1 staining was equal in intensity and distribution to EMA. In the HG cases Claudin‐1 staining was less intense and diffuse than EMA. Conclusion: There is a significant difference in the staining of LG and HG meningiomas with Claudin‐1 versus EMA. EMA is a more sensitive stain, however, as studies have shown EMA is not specific to meningiomas. Claudin‐1, on the other hand, lacks the sensitivity of EMA. Claudin‐1 as a singular stain in HG meningiomas may not be of benefit, however, used in conjuction with EMA, may be useful in confirming the diagnosis of meningioma. With further investigation, Claudin‐1 may prove to be of use as a prognostic marker in potentially helping to distinguish LG from HG meningiomas.