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Cytogenetic and Molecular gene array analyses of radiation‐induced meningiomas
Author(s) -
KleinschmidtDeMasters Bette K.,
Donson Andrew M,
Foreman Nicholas K,
Lillehei Kevin O
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a388-c
Subject(s) - monosomy , radiation therapy , radiosurgery , sarcoma , microarray , chromosome , meningioma , cancer research , medicine , microarray analysis techniques , biology , chemotherapy , gene , oncology , pathology , radiology , genetics , karyotype , gene expression
We studied 20 radiation‐induced meningiomas RIMs seen since 1993 for cytogenetic alterations and clinical outcome. Most were WHO grade I tumors. Abnormalities of chromosome 1p and/or LOH 1p36 was identified in 5 of 11 informative cases, with monosomy 22 in 4. Most could be managed surgically, either with a single extensive resection or with re‐resection. Several have shown no growth and have required no neurosurgical intervention. Stereotactic radiosurgery or radiation + chemotherapy have been used selectively (6). Affymetrix gene array study in 2 examples were compared to a large number of other tumors (n=52) and showed that RIMs clustered closely with radiation‐induced sarcoma and Ewing's sarcoma, but not with radiation‐induced glioblastomas. RIMs generally have a favorable prognosis, although therapy needs to be individually tailored. Gene microarray illustrates a more distinctive “signature” for RIMs than does cytogenetic analysis.