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The Effect of Haedokbangamtang3(HBT3), a mixture of herbal medicine, on cytokines in radiation‐induced inflammatory rat model
Author(s) -
Lee YuRim,
Kang JiIn,
Kim EunMee,
Kim KyoungOk,
Kang SeungHee,
Chun Mison,
Kim HyunSook
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a378-a
Subject(s) - medicine , tumor necrosis factor alpha , cytokine , inflammation , irradiation , radiation therapy , pharmacology , proinflammatory cytokine , cancer , anti inflammatory , immunology , physics , nuclear physics
Radiation is widely used as either diagnostic or therapeutic methods of various diseases. In anti‐cancer treatment, radiation inhibits the growth of cancer cells, but may induce inflammation in normal tissue. This study was aimed to investigate the effects of Haedokbangamtang3(HBT3), a mixture extracted from herbal medicines, on cytokines production (IL‐1β, IL‐2, IL‐6, IL‐10, IL‐12, IFN‐γ, and TNF‐α) in radiation‐induced inflammatory animal model. The whole pelvic cavity of female Wistar rat (180–200g) was irradiated with a single dose of 17.5 Gy using a linear accelerator, 6 MV. Either 300 mg/kg/day or 1000 mg/kg/day of HBT3 was orally administered for total two weeks from one week before irradiation. The animals were sacrificed at post‐irradiation week 6. The concentration of serum cytokines(IL‐1β, IL‐10, IL‐12) which was measured by ELISA assay decreased in the irradiation group treated with HBT3 of 1000mg/kg/day when compared with those in the non‐irradiation group. This study may suggest that HBT3 may have a potential effect as an anti‐inflammatory supplements which is characterized by suppressing cytokine production in radiation‐induced inflammatory rats. This work was supported by Brain Korea 21 project in 2006 and the SRC/ERC program of MOST/KOSEF. (Research center for women's diseases)