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Effects of isoflavones on body fat accumulation in neutered male and female dogs
Author(s) -
Pan Yuanlong
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a373
Subject(s) - fat accumulation , isoflavones , endocrinology , medicine , soy isoflavones , physiology , obesity
Increased incidence of overweight and obesity has been observed in neutered male and female dogs. This study investigated whether soy isoflavones reduced body fat accumulation, and a combination of isoflavones, L‐carnitine and conjugated linoleic acid (CLA) had synergistic effects on body fat accumulation in neutered male and female dogs. Neutered Labrador Retrievers with normal body weight were randomized into three groups: control, isoflavone, and blend. The dogs were fed 25% more than their maintenance energy requirements for 12 months. Body composition, thyroid function and blood biochemistry parameters were measured at the baseline and every three months after initiation of the feeding trial. Compared with the corresponding control dogs, the isoflavone diet reduced body fat accumulation in the neutered male dogs and neutered female dogs by 85% and 27%, respectively. CLA and L‐carnitine completely negated the isoflavone effects on body fat in the neutered male dogs, and slightly reduced the isoflavone effects on the body fat in the neutered female dogs. The isoflavone and blend diets did not significantly affect lean body mass, total white blood cells, thyroid hormone profile, and other blood biochemical parameters in the study. In summary, the isoflavone diet was very effective in reducing body fat accumulation in neutered dogs with the effects more pronounced in the male dogs.