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Intracerebroventricular administration of soy hydrolysates reduced body weight without affecting food intake
Author(s) -
Vaughn Nerissa,
Rizzo Anthony,
Doane Dolores,
Beverly J. Lee,
Mejia Elvira Gonzalez
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a372-d
Subject(s) - hydrolysate , leptin , chemistry , endocrinology , medicine , soy protein , body weight , weight loss , adipose tissue , food intake , receptor , weight gain , food science , obesity , biology , biochemistry , hydrolysis
Recent studies suggest that increased consumption of soy hydrolysates may cause weight loss but the mechanism of action is unknown. The objective of this investigation was to determine if intracerebroventricular (i.c.v.) infusion of recombinant rat leptin and soy protein hydrolysates react with receptors in the brain to decrease food intake and increase adipose depletion. Adult male Sprague Dawley rats (n=24) were injected 1 μg/5 μl i.c.v. twice weekly with leptin, and different concentrations for soy hydrolysate I (SH I) or soy hydrolysate II (SH II) for a period of two weeks. SH I (< 14 kDa) was produced with alcalase, and SH II (< 2 kDa) by fermentation. Soy peptides interacted in vitro with leptin soluble receptor. Leptin successfully reduced body weight (−2.9 g) and prevented weight recovery up to 48 h after injection (p < 0.05). SH I also reduced body weight (−2.8 g) however this effect was short of statistical significance (p < 0.08). There was a dose‐response tendency on reduction of body weight due to SH I (p < 0.09). Food intake was not affected by any of the treatments. Data suggest that SH can decrease, in the short term, the rate of weight gain and may play a role on body weight regulation. Supported by the Illinois Soybean Association and SAI Company