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(−)Epigallocatechin gallate hampers MMP activation in ultraviolet‐B irradiation‐induced human dermal fibroblasts: involvement of MAPK
Author(s) -
Bae JiYoung,
Choi YeanJung,
Choi JungSuk,
Kwon HyangMi,
Kang SangWook,
Kang YoungHee
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a368-a
Subject(s) - photoaging , matrix metalloproteinase , collagenase , mapk/erk pathway , chemistry , epigallocatechin gallate , signal transduction , phosphorylation , human skin , microbiology and biotechnology , catechin , skin aging , cancer research , biochemistry , enzyme , antioxidant , biology , medicine , polyphenol , dermatology , genetics
Ultraviolet (UV) irradiation is known to induce dermal production of matrix metalloproteinases (MMPs) and to degrade collagenous skin tissues. In this study, we mimicked the action of environmental ultraviolet on skin and investigated the mechanistic effects of (‐)epigallocatechin gallate (EGCG), a potent catechin component of green tea, on activation of MMP‐1, MMP‐8 and MMP‐13 in UV‐B irradiated human dermal fibroblasts by activating cellular signaling transduction pathways. EGCG differentially suppressed the production of all the MMP collagenases enhanced by UV‐B, followed by marked collagen degradation. EGCG rapidly and substantially blocked phosphorylation of both JNK and ERK1/2 in UV‐B‐exposed dermal fibroblasts. These results demonstrate that EGCG is able to hamper UV‐induced collagenase‐type MMP production via interfering with the JNK‐ and ERK‐responsive pathways. Therefore, EGCG may be a potential agent for the prevention and treatment of skin photoaging.