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Resistant starch in a high fat diet produces signaling from the gut, but not reduced body fat
Author(s) -
Tripathy Sasmita,
Loebig Shayna L,
Raggio Anne M,
Zhou Jun,
McCutcheon Kathleen L,
Hegsted Maren,
Tulley Richard T,
Martin Roy J,
Keenan Michael J
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a364-a
Subject(s) - peptide yy , proglucagon , endocrinology , medicine , leptin , cecum , chemistry , resistant starch , starch , glucagon like peptide 1 , biology , obesity , food science , type 2 diabetes , diabetes mellitus , neuropeptide y receptor , receptor , neuropeptide
This study examined the effects of resistant starch in a high fat diet (28% fat) on body weight, abdominal fat, cecal weight and pH, serum gut peptide YY (PYY) and gene expression for PYY and proglucagon in male Sprague Dawley rats. Three groups of rats (8wk) were fed one of these diets for ten wks: energy control (EC; 3.7 kcal/g), resistant starch (RS; 3.7 kcal/g) and fiber control (FC; 2.9 kcal/g). Results were significant when p ≤ 0.05. The consumption of RS resulted in significant increases in cecal weight (full and empty), serum PYY, gene expression for PYY and proglucagon in cecum, and significant decrease in cecal pH compared to the other groups. However the disemboweled body weight and abdominal fat for RS were not lower compared to the EC. In previous studies, we observed that RS in a low fat diet (18% of fat), produced similar gut signaling, as in current study, but reduced disemboweled body weight and abdominal fat compared to EC. Mechanism for the contradictory results needs further study. Since high fat diets have been shown to alter brain response to other satiety signals (leptin), a high fat diet might affect neuronal response to PYY and GLP‐1 signaling from the gut caused by dietary RS.