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Redox regulation of progenitor cell function in development and pathology
Author(s) -
Noble Mark
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a36-b
Subject(s) - microbiology and biotechnology , redox , regulator , progenitor cell , cell fate determination , function (biology) , intracellular , biology , extracellular , chemistry , biochemistry , stem cell , transcription factor , organic chemistry , gene
The remarkable sensitivity of cellular function to small (e.g. 15–20%) changes in redox state indicates that physiological regulation of intracellular redox status is a central regulator of division, differentiation and death. I will discuss our findings on the developmental roles of redox control, the essential role of redox state modulation in the mechanism of action of a wide range of signaling molecules (including, e.g., FGF‐2, NT‐3, thyroid hormone, BMPs) and the complementary role of redox status in controlling responsiveness to these and other extracellular stimuli, the ability of progenitor cell redox state to dictate vulnerability to physiological stressors of the differentiated cells they generate, and some of the novel mechanistic principles we have discovered regarding how redox status modulates cell function. I also will discuss our recent discoveries that chemically diverse environmental toxicants, by virtue of their pro‐oxidant activity, modulate progenitor cell function via convergence on a single redox‐modulated regulatory pathway. (Research supported by NIH, Wilmot Foundation)