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Dietary Magnesium Intake, Inflammation, and Atherosclerotic Plaque Development in Rabbits
Author(s) -
King Jennifer L,
Miller Rita J,
Blue James P,
Zachary James F,
O'Brien William D,
Erdman John W
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a359
Subject(s) - inflammation , medicine , c reactive protein , cholesterol , endocrinology , lipid profile
An inverse association between dietary magnesium (Mg) and cardiovascular disease (CVD) incidence suggests that habitually high intake of foods rich in Mg protects against CVD. Marginal deficiency of Mg has been associated with sub‐clinical inflammation, including increases in C‐reactive protein (CRP) levels. Americans who consumed less than 50% of the RDA for Mg were 2.24 times more likely to have elevated CRP levels than those who consumed the RDA. Mg deficiency has been shown to accelerate cardiovascular lipid deposition and a large amount of evidence supports the paradigm of inflammation and endothelial dysfunction as the common link between risk factors and atherosclerotic burden in CVD. Four‐month‐old rabbits were fed a high‐fat cholesterol‐containing diet with 0.11%, 0.25%, or 0.40% Mg. Serum samples will be analyzed for cholesterol, thrombomodulin, CRP, and Mg levels. Aortas will be fixed and stained with Sudan IV to assess atherosclerotic plaque development. (Supported by NIH Grant #RO1 EB002641)