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Associations of dietary protein, calcium, potential renal acid load, and bone mineral density in elderly women
Author(s) -
Thorpe Matthew P.,
Mojtahedi Mina C.,
ChapmanNovakofski Karen M.,
McAuley Edward,
Evans Ellen M.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a357-c
Subject(s) - calcium , bone mineral , medicine , endocrinology , phosphorus , potassium , nutrient , population , osteoporosis , zoology , chemistry , biology , organic chemistry , environmental health
The interactive influence of protein intake and calcium intake on bone health in older individuals is incompletely characterized. Current theory posits that although protein has a net beneficial influence on bone, the associated metabolism of sulfur‐containing amino acids and phosphorus imposes an acid load to the body which is buffered by bone‐demineralization. The aim of this study was to explore the relations between dietary protein, calcium, potential renal acid load (PRAL), net endogenous acid production (NEAP), and bone mineral density (BMD) in elderly women. Women (n = 169, M±SD 67.9±6.0 y) were assessed for dietary intake using 24 h recalls, lumbar spine (LS) and proximal femur (PF) BMD via dual energy X‐ray absorptiometry (DXA), PRAL was calculated from dietary protein, calcium, magnesium, potassium and phosphorus and NEAP estimated from dietary protein and potassium. ANOVA testing revealed a significant interaction between tertiles for protein intake and supplemental calcium at the LS ( p <0.05) and a trend at the WB (p=0.054) and PF ( p =0.059), however no clear pattern of group differences appeared in post‐hoc testing. These results suggest that protein in a weight‐stable diet may not promote bone health in an elderly female population, even after controlling for estimates of the associated acid load. Funded by NIH R01‐ AG020118 and the UIUC Research Board.