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The effect of feeding different sugar sweetened beverages on the bone health of female rats
Author(s) -
Tsanzi Embedzayi,
Light Heather,
Tou Janet
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a356-c
Subject(s) - fructose , chemistry , sugar , bone mineral , sucrose , endocrinology , excretion , urine , food science , medicine , zoology , osteoporosis , biology , biochemistry
Consumption of sugar sweetened beverages has increased among adolescents, particularly as high fructose corn syrup (HFCS) yet the effects of high sugar intake during growth on skeletal acquisition and adult bone health are unknown. The objective of this study was to determine the effect of feeding different sugar sweetened beverages to growing rats and its impact on bone mineral density (BMD) and bone strength at maturity. Immature (3 weeks old) female Sprague‐Dawley rats (n=8–9/group) were randomly assigned to be given deionized distilled water (ddH 2 O), or ddH 2 O containing 13% w/v of either: glucose, sucrose, fructose or HFCS‐55. Food intake, urine and fecal output were measured weekly. At the end of the 8 weeks studies, both tibiae and femurs were collected. BMD was determined by DEXA and bone strength by three‐point bend test. Urinary/fecal calcium (Ca) was determined using inductively coupled plasma mass spectrometry. Results showed tibial and femoral BMD of rats fed glucose was reduced (p<0.001) by 3–8% compared to rats fed the other sweetened beverages. Despite reduced BMD, there was no signification decrease in bone strength. Rats fed the glucose beverage had the lower Ca intake (p<0.001) and Ca excretion (p< 0.05) compared to the other groups. Results indicated that high glucose consumption may reduce BMD by decreasing Ca intake. Other possible mechanisms may be by direct effects on bone.