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Bone modeling is affected in school children by Overweight and Obesity.
Author(s) -
Rio María Esther,
Piazza Norma,
Dupraz Hernán,
Pellegrini Gretel,
Somoza Julia,
Zeni Susan
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a356-a
Subject(s) - overweight , obesity , urine , endocrinology , medicine , bone resorption , basal (medicine) , calcium , creatine , body mass index , bone mineral , resorption , chemistry , osteoporosis , diabetes mellitus
Cross‐sectional studies support a relationship between obesity and reduced calcium intake (Ca I) but the point is still controversial. In previous studies we observed low bone mineral density in children presenting overweight (OW) or obesity (O) and low Ca I. The α‐CTX is a non‐isomerized form of bone resorption biochemical marker that reflect degradation of young bone, whereas calcium/creatine (Ca/C) in basal urine is used to assess usual Ca I. The aim of this preliminary study was to analyze the influence of body weight on the relationships between α‐CTX and Ca/C in a group of prepubertal children attending public schools of Vicente López, GBA: 38 girls and 40 boys: (n=78) ranging between 6 to 10 years that according to their present body mass index (BMI) were distributed in normal (N: n=46), OW (n=20) or O (n=12) using NCHS tables. Basal urine Ca (mg) and C (mg) were assessed by conventional methods. The α‐CTX (ng) was determined by ELISA (Nordic Bioscience Diagnostic). A significant correlation between α‐CTX/C vs Ca/C (r=0.40 p<0.012) was found in N. Alfa‐CTX levels were higher in N than in OW or O: 943±313 vs 850±278 and 891±123 ng/mg, respectively. Although number of cases was not enough to reach significance, results suggest that low Ca I affected differently bone modeling in those children with abnormally high body weight, regarding to normal. Supported by UBACyT. Social Urgency Project B/703.