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Bixin stimulates immune response in cats
Author(s) -
Park Jean Soon,
Hayek Michael G.,
Ceddia Michael A.,
Reinhart Gregory G.,
Chew Boon P.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a353-a
Subject(s) - immune system , cytotoxicity , histamine , concanavalin a , cytotoxic t cell , immunology , biology , respiratory burst , microbiology and biotechnology , chemistry , pharmacology , biochemistry , in vitro
Studies on its immune modulatory action is lacking. Female domestic cats (3 yr old) were fed daily for 16 wk with 0, 1, 5 or 10 mg bixin (n = 14/group). Blood was sampled on wk 0, 6, 12 and 16. All cats were then vaccinated with an attenuated polyvalent vaccine on wk 12 and 14. Skin hypersensitivity response (DTH) to saline, concanavalin A, the vaccine, and histamine was assessed on wk 12 and 16. Lymphoproliferation, leukocyte subpopulations, NK cell cytotoxicity and Ig production were assessed. Acid glycoprotein concentrations and DNA damage were determined in plasma. Cats fed 1 mg bixin showed enhanced NK cytotoxicity and DTH response to vaccine, and suppressed acid glycoprotein concentration and DNA damage. Those fed 5 mg bixin generally showed the highest immune stimulatory and antioxidative action. In this treatment, bixin enhanced lymphoblastogenic response, populations of T helper and T cytotoxic cells, NK cytotoxicity and IgG production; bixin also inhibited DNA damage. At 10 mg, bixin stimulated DTH response to con A, percent of total T and T cytotoxic cells, and IgG production; however, it inhibited mitogen‐induced lymphocyte proliferation. All doses of bixin reduced skin response to histamine and CD18 subpopulations. Therefore, dietary bixin, especially at the 5 mg dose, heightened cell‐mediated and humoral immune response, and inhibited DNA oxidative damage and inflammation in cats.