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MATERNAL FOLIC ACID STATUS AFFECTS ON THE SYNTHESIS OF CEREBRAL MYELIN BASIC PROTEIN IN THE OFFSPRING.
Author(s) -
Kim Soo Jung,
Chae Eun Hye,
Lee Hwayoung,
Kim JiMyung,
Roh Seung Ju,
Chang Nam Soo
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a345-a
Subject(s) - offspring , weaning , pregnancy , homocysteine , medicine , lactation , endocrinology , folic acid , myelin basic protein , physiology , biology , central nervous system , myelin , genetics
We hypothesized that maternal folic acid nutrition status might affect the synthesis of cerebral MBP in the offspring. Female rats were fed either folic acid sufficient or deficient (8 or 0mg/kg diet) diet from 2 wks prior to the mating till the entire pregnancy and lactation. After weaning, the offspring of folic acid deficient group were divided into 2 groups and were fed either folic acid sufficient or folic acid deficient diet for 4 weeks. The maternal folic acid deficiency caused a significant decrease in plasma folate and hepatic SAM/SAH ratio with a concomitant increase in plasma homocysteine in their offspring. Folic acid supplementation during the weaning period made plasma folate and homocysteine level, and hepatic SAM/SAH ratio comparable to those who were maintained on a folic acid sufficient diet throughout the entire experimental period. Compared to the folic acid sufficient group, maternal folic acid deficiency caused a significant decrease in the expression of MBP in the spinal cord. Folic acid supplementation during the weaning period failed to cause an increase in the expression of MBP in the spinal cord. These results suggested that maternal folic acid status may affect the synthesis of MBP and thus influence the development of myelin in their offspring. This work was supported by Korea Research Foundation Grant Funded by the Korean Government (KRF‐2005‐C00088‐I00261).