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Enhanced metabolic flexibility with long term weight reduction facilitates weight regain in obesity‐prone rats
Author(s) -
Jackman Matthew,
Johnson Ginger,
FlemingElder Brooke,
Bessesen Daniel,
MacLean Paul
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a343-a
Subject(s) - thermogenesis , obesity , endocrinology , medicine , weight loss , adipose tissue , metabolism , energy expenditure , chemistry , meal , peripheral , zoology , biology
Weight reduction (WR) induces a number of metabolic adaptations that promote obesity relapse, including a pronounced energy gap between the drive to eat and energy expenditure. We examined how peripheral fuel metabolism is altered with WR. A dual‐tracer approach (i.p. 3 H 2 0 and dietary 14 C‐palmitate) was used with indirect calorimetry to assess absorption and the metabolism of ingested fats during relapse. Rats were examined in the Obese state, after 10wks of WR (RED), and on the first day of relapse (REL). An additional group was provided the diet to match the positive energy gap (~9kcal) observed in the Obese (gap‐matched, GM). Obese consumed small meals throughout the day and exhibited a sustained, unchanging level of fat oxidation. RED exhibited a diurnal fluctuation in fat oxidation, in part due to the availability of the diet. The capacity to shut off fat oxidation was maximized in REL, which displayed a preferential use of carbohydrates, suppressed fat oxidation, and the trafficking of dietary fats to adipose tissue. Despite a similar energy imbalance to Obese, GM exhibited a shift in fuel utilization that was similar to REL rats. These data suggest that WR enhances the capacity of peripheral tissues to suppress fat oxidation and that this adaptation works in concert with the large energy gap during relapse to promote rapid, efficient weight regain.