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Continuous intravenous infusion of trans ‐10, cis ‐12 conjugated linoleic acid (CLA) acutely inhibits milk fat synthesis
Author(s) -
McFadden Joseph W.,
Campbell Davina E.,
Herbein Joseph H.,
Lengi Andrea J.,
Wark Wendy A.,
Corl Benjamin A.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a341-b
Subject(s) - conjugated linoleic acid , chemistry , milk fat , fatty acid , linoleic acid , lactation , food science , medicine , biochemistry , biology , linseed oil , pregnancy , genetics
A progressive decline in milk fat production is observed with minimal doses of trans ‐10, cis ‐12 CLA. In a cross‐over design, 6 cows were milked every 4 h during the first 24 h and every 12 h from 24 through 96 h post infusion. Cows were continuously infused intravenously with an emulsion providing 15 g/d of trans ‐10, cis ‐12 CLA. Milk fat content of trans ‐10, cis ‐12 CLA increased throughout infusion peaking at 0.35 g/100 g FA; however, rate of CLA incorporation in milk fat was highest during the first 24 h. Milk and milk protein yield were not affected by treatment. Protein content was significantly increased at 96 h (3.47% vs 3.18% at 0 h). Infusion of CLA resulted in a significant reduction in milk fat content and yield, by 49% and 52%, respectively. Milk fat content was significantly reduced at 12 h and reached a nadir at 36 h (2.10% vs 4.28% at 0 h). Milk fat yield (g/h) progressively declined post infusion and was significantly reduced by 20 h (29 vs 53 at 0 h). Concentration of milk fatty acids containing less than 16 carbons was reduced by 8% at 36 h and by 17% at 96 h. Trans ‐10, cis ‐12 CLA was shown to have an acute regulatory role in the inhibition of fatty acid synthesis in the mammary gland.