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Statins prevent the expected rise in serum total and lipoprotein cholesterol levels while consuming up to 1000 mg per day of cholesterol as egg yolk
Author(s) -
Nicolosi Robert J,
Goodrow Elizabeth,
Wilson Thomas
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a340-b
Subject(s) - yolk , cholesterol , lipoprotein , medicine , zoology , ldl cholesterol , total cholesterol , saturated fat , endocrinology , biology , food science
Sixty‐five adults ≥ 60 years of age and taking various statins for at least 3 months, are being recruited into an egg‐feeding study of age‐related macular degeneration. At this point, 26 participants have completed the 18‐week sequential study consisting of 4 phases. Phases 1 (baseline) and 3 are 4 week periods each during which time participants are instructed to refrain from consuming eggs. During phases 2 and 4, individuals consume food items containing the equivalent of 2 and 4 egg yolks per day, respectively for 5 weeks. Serum lipid and lipoprotein levels are being determined twice for each phase in a CDC/NHLBI lipid standardized laboratory. Unexpectedly, not only did serum lipids not rise with cholesterol intakes up to 1000 mg/day, but LDL‐C was reduced 10% (p<0.003) and HDL‐C increased 7% (p<0.002) in participants consuming the equivalent of 4 eggs/day. 7DDR at each phase do not support a decrease in saturated fat intake with increasing egg consumption In conclusion, statins appear to regulate serum total and lipoprotein cholesterol levels even in the presence of elevated dietary cholesterol intakes. Supported by the American Egg Board, Egg Nutrition Center, Washington, DC and The Massachusetts Lions Eye Research Fund Inc., New Bedford, MA.