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Latent stem cells in the zebrafish post‐embryonic neural crest
Author(s) -
Parichy David M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a34-b
Subject(s) - zebrafish , danio , neural crest , biology , embryonic stem cell , stem cell , microbiology and biotechnology , developmental biology , adult stem cell , embryogenesis , gene , genetics , anatomy , neuroscience
Post‐embryonic neural crest‐derived stem cells have been identified in a variety of systems and have clear biomedical significance. The zebrafish Danio rerio provides an opportunity to study factors required for the establishment, maintenance, and recruitment of these cells to particular lineages. One trait that depends on these cells for its development is the adult pigment pattern, which arises from latent precursors during the larval‐to‐adult transformation. Here, I describe recent mutational and pharmacological studies that identify roles for several genes in the development of these cells, as well as critical periods for gene activities. These analyses highlight the utility of zebrafish for studies of stem cell biology as well as post‐embryonic development more generally.