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Initial plasma plant sterol concentrations do not predict changes in plasma lipids and plant sterols following intake of a plant sterol‐enriched food
Author(s) -
Houweling Adrielle H,
Vanstone Catherine A,
Trautwein Elke A,
Duchateau Guus SMJE,
Jones Peter JH
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a337-c
Subject(s) - sterol , cholesterol , chemistry , medicine , endocrinology , plasma concentration , zoology , absorption (acoustics) , plant sterols , plasma lipoprotein , food science , lipoprotein , biology , biochemistry , physics , acoustics
Background: Plant sterols (PS) effectively lower plasma TC and LDL‐C concentrations, while minimally elevating PS concentrations. Initial plasma PS concentrations, however, may reflect sterol absorption. Accordingly, reductions in plasma TC and LDL‐C and elevations in PS may differ between individuals with initially high (HPS) and low (LPS) plasma PS concentrations after dietary PS intake. Objective: To examine whether HPS and LPS plasma concentrations are related to subsequent changes in plasma PS and cholesterol concentrations, following dietary PS intake in otherwise healthy hypercholesterolemic men. Design: This single‐blinded, randomized, controlled study consisted of two 4‐week phases, separated by a 4‐week wash‐out, whereby a diet with a placebo or the 1.8 g/d PS‐enriched spread was consumed. Results: Following PS intake, plasma PS concentrations were elevated from 34.59 to 46.17 μmol/L and 16.45 to 20.8 μmol in HPS and LPS groups, respectively; while percent changes were not different between groups. TC and LDL‐C concentrations were decreased (p<0.0001) by 6.3 and 7.8 %, for all individuals. Changes in lipid parameters were not different between groups. Conclusions: In view of these data, a supplement of 1.8 g/d of PS should be viewed as a beneficial cholesterol‐lowering therapy that minimally elevates plasma PS concentrations to the same extent for all healthy individuals, with respect to their initial plasma PS concentrations. Acknowledgements: This research was funded by Unilever R&D, The Netherlands.