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Essential amino acid supplementation on muscle function and stair ascent/descent following 10 days of bed rest in older adults
Author(s) -
Symons Brock,
Lombeida Juan,
Protas Elizabeth,
Kortebein Patrick,
PaddonJones Douglas,
Ferrando Arny,
Wolfe Robert,
Evans William
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a337
Subject(s) - placebo , isometric exercise , medicine , bed rest , physical therapy , physical medicine and rehabilitation , alternative medicine , pathology
Prolonged inactivity in elderly individuals causes a loss of lean muscle mass and compromises strength and function, which may impair subsequent rehabilitation and the ability to perform daily activities. We examined the effects of essential amino acid supplementation (EAA) on isometric (ISO) and isokinetic concentric (CON) torque and stair ascent/descent power after 10 days of bed rest in older adults. Twenty women and men (placebo: n=12, 67 ± 5yrs and EAA: n=8, 67 ± 5yrs) participated. During bed rest, subjects consumed an EAA supplement (15g,3*/day) or placebo. Knee extensor ISO (45°) and CON (60 & 180°·s −1 ) peak torque were measured. Stair ascent and descent power were assessed over ten steps (body weight*9.8*distance/time). The placebo group experienced larger reductions in ISO and CON 60°·s −1 peak torque and stair ascent and descent power than the EAA group (−11.1 to −18.2%); while the EAA group demonstrated a larger decrease in CON 180°·s −1 peak torque (−16.1±5.3%) than the placebo group. No difference was found between the placebo group and the EAA group for any of the outcome measures ( p >0.112). In older adults, 10 days of strict bed rest decreased muscle strength and stair ascent/decent power. The EAA group exhibited smaller reductions; however, these reductions did not differ from the placebo group. AG 023591, MO1 RR 00073