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Effect of nutrient composition of the diet on the variation of plasma hormone concentrations during waking hours in lean and overweight humans.
Author(s) -
Bohan Michelle M,
Anderson Lloyd L,
Trenkle Allen H,
Beitz Donald C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a321
Subject(s) - overweight , endocrinology , medicine , ghrelin , appetite , leptin , hormone , adiponectin , obesity , insulin , insulin resistance
Investigating the role of appetite‐related hormones on energy balance and body composition when varying diets are consumed could provide insight into the etiology of obesity. Eight female and eight male subjects, ages 20–30, were used in this study: four normal weight subjects with BMI of 19–24 and four overweight subjects with of BMI of 27–30 of each sex. Each subject received both treatments by a crossover design. Two normal and two overweight subjects were assigned to the Atkins' diet. The Atkins' diet contained 10% of energy as carbohydrate, 45% of energy as protein, and 45% of energy as lipid. The remaining two normal and two overweight subjects were assigned to the AHA diet that contained 63% of energy as carbohydrate, 12% of energy as protein, and 25% of energy as lipid. Each diet was fed for 14 days, and then subjects switched to the other diet. Blood was taken every hour from 7 am to 9 pm on days 13 and 27 of the study. Plasma samples were analyzed for active and total ghrelin, leptin, insulin, glucagon, growth hormone, and adiponectin. We hypothesized that subjects consuming the Atkins' diet will have different plasma hormone concentrations over a 14 hour period than subjects consuming the AHA diet. Hormone concentrations responded differently to diet, weight, time point, period, and interactions of these variables. These results indicate a relationship of appetite‐related hormones with respect to diet composition.