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Optical coherence tomography for embryonic cardiography
Author(s) -
Rollins Andrew M.,
Jenkins Michael W.,
Chugtai Osman,
Patel Pankti,
Watanabe Michiko,
Deng Huayun,
Montano Monica M.,
Rothenberg Florence
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a3
Subject(s) - optical coherence tomography , embryonic heart , embryonic stem cell , preclinical imaging , in vivo , cardiac imaging , high resolution , molecular imaging , biology , biomedical engineering , anatomy , medicine , radiology , genetics , remote sensing , gene , geology
We have developed tools based on optical coherence tomography (OCT) capable of imaging the structure and function of very early embryonic hearts. OCT is an emerging optical modality capable of high spatial resolution (2–15 μm) and high temporal resolution (hundreds of frames per second) imaging in vivo , non‐invasively with penetration of 1–2 mm through cardiac tissue. We have demonstrated in vivo 4D imaging of avian embryonic hearts by use of gated OCT. We have shown that OCT can characterize the morphological phenotype of embryonic murine hearts, discerning HEXIM1 mutants from their wild type littermates at stages E12.5 and E13.5. OCT provides a unique and valuable imaging tool for developmental cardiology research.