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Zymergomics: Integration of Bioinformatics and Process Laboratory Biochemistry
Author(s) -
Elliott Mark Stuart,
Morris Rana C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a297
Subject(s) - computational biology , metabolomics , yeast , proteome , systems biology , process (computing) , cornerstone , biology , microbiology and biotechnology , biochemistry , computer science , bioinformatics , art , visual arts , operating system
Alcohol is a cornerstone of modern civilization. It is a food, a fuel, a drug, a solvent.. Both the yeast and its physiological processes producing alcohol are well characterized and have been used as a model system in molecular genetics, biochemistry and physiology laboratory courses. Here, we outline a two‐semester undergraduate laboratory course in Zymergomics that will enable a comprehensive, integrated study of this scientifically and commercially important system. The first semester will study “The Cellular Biology and Molecular Genetics of Yeast”, which involves analysis of the Saccharomyces genome, transcriptome and proteome. The second semester is the study of “The Biochemistry of Yeast and Fermentation”, involving the proteomic, enzymological and metabolomic analysis of the fermentation process. Bioinformatics methods of database mining and management will be employed in pre‐ and post‐laboratory data analysis. Many topics and techniques employed here can be cost‐effectively implemented into existing traditional semester‐long Molecular Biology and Biochemistry Laboratories.