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Effects of a Fructose Diet in SHRSP
Author(s) -
Brosnan M Julia
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a293-b
Subject(s) - fructose , insulin resistance , medicine , endocrinology , blood pressure , metabolic syndrome , oxidative stress , diabetes mellitus , insulin , chemistry , biochemistry
The increased consumption of refined sugars, such as fructose corn syrup, has been associated with the increased prevalence of metabolic syndrome and diabetes. The underlying mechanisms remain obscure but have been linked with oxidative stress. This study aimed to determine the metabolic effects of feeding a high fructose diet to the stroke prone spontaneously hypertensive rat (SHRSP) a model particularly vulnerable to insulin resistance. Male SHRSP, pre‐implanted with telemetry devices, were fed 60% fructose and the effects on insulin resistance determined by a glucose tolerance test. Blood pressure, heart rate and activity were determined by telemetry. Levels of expression of anti‐oxidant enzymes including MnSOD, CuZnSOD and ECSOD were measured by immunoblotting. Feeding SHRSP a high fructose diet resulted in profound insulin resistance accompanied by elevations in plasma triglycerides. Systolic blood pressure, however, was significantly reduced in fructose‐fed SHRSP compared with chow‐fed rats. The hepatic expression of the three isoforms of superoxide dismutase was increased. These results suggest that a diet high in fructose contributes to insulin resistance and that alterations in the expression of anti‐oxidant enzymes may contribute to the reduction in blood pressure.