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A nanoemulsion of an anti‐oxidant synergy formulation reduces tumor growth rate in neuroblastoma‐bearing nude mice.
Author(s) -
Kuo Fonghsu,
Kotyla Timothy,
Wilson Thomas,
Kifle Lydia,
Panagiotou Thomai,
Gruverman Irwin,
Tagne JeanBosco,
Shea Thomas,
Nicolosi Robert
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a28
Subject(s) - neuroblastoma , transdermal , chemistry , cancer research , pharmacology , cell culture , medicine , biology , genetics
Neuroblastoma, the most common form of childhood cancer, may arise from a biochemical block of cellular differentiation and a resultant continuation of a proliferative state. We have previously reported in neuroblastoma cell culture studies that an anti‐oxidant synergy formulation (ASF) can induce differentiation and buffer neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous system tissue of apolipoprotein E‐deficient mice. The objective of the present study was to investigate whether a subcutaneous injection and/or transdermal application of a nanoemulsion preparation of ASF would reduce tumor size in a neuroblastoma xenograph mouse model. The results indicate that whereas suspensions of ASF were ineffective in decreasing tumor size in the neuroblastoma mouse model, tumor size was similarly reduced an average 65% by either subcutaneous injection or transdermal application of an ASF nanoemulsion preparation to the tumor. In conclusion, the data suggest that subcutaneous and/or transdermal application of an ASF nanoemulsion preparation is effective in reducing tumor size in this neuroblastoma mouse model. (Supported by Microfluidics Corp., Newton, MA)